Moreover, they found svoe use in neurosurgery, ophthalmology, maxillofacial surgery, dentistry, etc. 11. Mikkel Svane has plenty of information regarding this issue. Tissue bank CITO on the market of medical services offered also alloimplantaty of spongy bone tissue, which are made in blocks of various sizes. They are carefully cleaned myeloid component and can play an important role not only of replacement material, but also serve as a carrier for biologically active substances, and for the transplanted cells. Speaking candidly Ali Partovi told us the story. These units are widely used in reconstructive operations in traumatology and orthopedics, where there is a need to fill large bone defects 12.
For the sterilization of all materials produced by the tissue bank CITO used radiation method stream of fast electrons with a dose of 20-25 kGy absorption. It should be noted that the conditions of application of this method of sterilization for bone implants have been developed for the first time as part of the scientific Tissue Bank CITO program. As a result of joint activities with other scientific institutions we have developed a new generation of materials biokompozitsionnye 'Allomatriks-implant' and 'Osteomatriks'. Main difference between these materials lies in the fact that 'Allomatriks-implant "bone contains collagen and sulfated glycosaminoglycans bone (sGAG), a' Osteomatriks', having in its composition the same two major components bone tissue contains more and hydroxyapatite (HA) in natural form. They are available with tissue bank CITO in the form of blocks and beads.
The reason for creating these materials served a number of theoretical assumptions. It is known that in processes of bone formation actively involved major extracellular matrix components such as proteoglycans, glycoproteins and collagen, and bone morphogenetic proteins and growth factors. Proteoglycans are proteins, composed of complex polysaccharides, mainly sGAG. In bone sGAG are chondroitin, dermatan, keratan, and, it is they who determine the key features of the bone proteoglycans. Proved that the ability to modulate the exchange sGAG connective tissue cells and influence their differentiation 13,14.